Refresh Checked Unchecked Menu Search Shopping bag Geolocation Person Facebook Instagram Twitter YouTube Info Icon CBC Icon CBC Shape CBD Icon CBD Shape CBG Icon CBG Shape THC Icon THC Shape THCV Icon THCV Shape
Advertise on Leafly

Is CBD the Next Big Thing for Acne?

July 10, 2017
(Jacob Ammentorp Lund/iStock)
Blackheads? Zits? Say goodbye to acne with a brand new cure—synthetic cannabis!

That, at least, is the hope of Botanix Pharmaceuticals Ltd., a dermatological company that just announced the completion of its Phase 1 clinical trial for an acne drug that incorporates synthetic cannabidiol (CBD). Called BTX 1503, the goal is that the drug could one day be an answer to acne.

Botanix began clinical trials of the drug in Australia last year. Twenty participants, all without acne symptoms, applied the synthetic cannabinoid-based topical over the course of a month to test its safety, tolerability, and pharmacokinetics (the amount of the drug detectable in the bloodstream after use).

The company plans to start a pilot program for acne patients later this quarter.

Clinical trials tend to be expensive, lengthy, and uncertain. A Phase 1 Study is preliminary—it determines whether a drug is safe enough to test on actual patients. Botanix managed to complete its Phase 1 trial within 12 months, and they say it has been a huge success. “Top line data demonstrates that BTX 1503 has an excellent safety profile, with little to no skin irritation, and no severe adverse events were recorded,” the company said.

Botanix attributes the relatively small levels of the drug which were recorded in participants’ bloodstreams to its so-called Permetrex delivery technology. According to the company, the product “ensures that the majority of BTX 1503 is delivered across the outer layer of the skin and into skin tissue,” rather than entering the bloodstream.

Related

Australian Study Aims to Unlock the Potential of a Little-Known Cannabinoid

The company plans to start a pilot program for acne patients later this quarter.

Why synthetic cannabidiol for acne? Although acne affects millions and has been studied extensively, there are relatively few effective medications that are free from side effects. While CBD as a treatment for acne isn’t very well studied, Botanix points to one 2014 academic paper published in the Journal of Clinical Investigation. That study used biopsies of human scalp and arm skin to try to determine whether CBD could suppress acne.

The researchers found that CBD inhibited both lipogenic action (the way the body converts energy to fat for storage), and the production of sebocytes (cells in the sebaceous glands which produce the oil which coats the hair and skin of mammals). Both processes are known to contribute to acne. The study also suggested that CBD had an anti-inflammatory effect on the skin. An important caveat, however, is that the study didn’t test CBD on actual, living humans.

Now Botanix is trying to put the research to the test in human trials.

The use of synthetic CBD, which doesn’t require growing cannabis plants, allows the company to avoid certain regulatory obtacles, which is one factor behind the company’s quick movement in the sector.

Meantime, Nasdaq-listed Zynerba Pharmaceuticals has been conducting, in collaboration with Aussie contract research organization Novotech, a Phase 1 study in Australia of its drug ZYN002, a synthetic CBD formulated to be a gel. The product, applied to the skin, is aimed at treating epilepsy and osteoarthritic knee pain. The says the clear gel is designed to provide consistent, controlled, and sustained drug delivery in twice-daily dosing.

  • Open Minds

    This is old news for anybody that’s involved in studying the Endocannabinoid System. Acne, like most other diseases, results from an imbalance in the body of the acne sufferer. What does the Endocannabinoid System do? It maintains homeostasis in the human body.

    http://www.thctotalhealthcare.com/category/acne/

    In addition, there is no need to use synthetic cannabinoids when you can use cannabis oil. Moreover, studies show that anandamide plays a role in skin health as well. But since THC gets you high, this drug company is going the CBD route only, forgoing the power of the Entourage Effect.

    By the way, who is Joe Wilson, the person who wrote this article? I looked up his profile on Leafly contributors and it’s blank. What’s up with that?

  • Open Minds

    So what happened to my comment? How do you expect to have lively debates? What a joke…