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7 factors that affect your cannabis high

June 27, 2019
(CSA Images/iStock)
Ask a dozen smokers what their favorite strain is, and you may receive a dozen different answers. Some prefer their high to be mellow, others like it buzzy, some want to feel it in their body, and others yet, in their head. There are a lot of factors that go into personal preferences when it comes to enjoying cannabis, but there are also many factors outside of simple likes that can affect your high.
By understanding the circumstances that can affect your high, you can empower yourself to have better experiences with a variety of strains and narrow down what works best for you.

Here are seven factors that affect your cannabis high.


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Set & setting

Your environment plays a crucial role in the effect of your cannabis high and should not be taken lightly. Sometimes, if you smoke the same strain on two different days, you can have very different experiences.

Next time this happens, ask yourself—what was your mood and environment like before you smoked? Were you relaxed, happy, comfortable? Tense, anxious, or uneasy? At ease with the people in your company? Out in nature, or in a crowd?


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Different scenarios can wildly affect your high. It’s important to consider your comfort level before indulging. Perhaps you know that getting high before you have to enter a stuffy waiting room will make you feel anxious, or maybe you know the best time for you to indulge is right before bed.

By being aware of your surroundings, you can figure out what set and setting work best for you, and better prepare yourself for enjoying the best possible cannabis high.

Delivery method

Smoking, vaping, and eating edibles may all be ways to ingest cannabis, but every delivery method comes with its own variables. Eating a pot brownie and hitting a vape will, generally speaking, affect you differently. Your body processes cannabis from each method differently, and the amount you consume usually differs between methods. On top of that, the duration of a high with edibles can be much longer, and the effects are often reported as stronger.


Which Is More Potent, Vaping Cannabis or Smoking a Joint?

It’s also easier to control your dose with some methods more than others—vaping for example, as opposed to eating an edible. Additionally, you can get a more potent hit from dabbing oil than from puffing on a joint, and it’s easier to visualize how much you’re consuming with a joint than with a vape. All of these factors can play a role, affecting the quality and length of your cannabis high.

As a result, it’s important to know your own limits with each individual method. Just because you can smoke a blunt every evening doesn’t necessarily mean you’ll enjoy half a pot brownie.


Dosing can be tricky, especially when indulging in edibles or a new strain. Starting low and going slow is essential.

Dosing may in fact be the most important factor to take into account when considering what will affect your high. Too little and you may feel like you shouldn’t have even bothered; too much and you may wind up sunk in the couch waiting for the high to wear off while the sound of the neighbor’s lawn mower freaks you out (I’ve been there too).


Edibles dosing chart: Interpreting potency in infused cannabis products

Hitting that sweet spot, and knowing what your sweet spot is, can make a world of a difference when enjoying cannabis.

Cannabinoid profile

Currently, the cannabinoid profile of a strain is one of the best and most accessible ways to determine how a high will affect you. For example, some people really enjoy the effects of cannabis’ most famous cannabinoid, THC, while others find its effects too stimulating or may have bad reactions from it, like anxiety.

There are other cannabinoids to consider as well, such as CBD and more. Cannabinoid profiles can be diverse and vary widely from strain to strain, but they can also be a powerful tool in assessing how a strain will affect your high.


CBD vs. THC: What’s the difference?

But it’s necessary to first know how each cannabinoid makes you feel, and this usually requires some experimenting. Once you know which ones work best for you, knowing the composition of a strain will put the power in your hands and will allow you to have the type of high you want.

However, the buck doesn’t quite stop there—other factors can come into play, such as the CBD:THC ratio of the strain, as THC can enhance CBD. Therefore, it is possible to have an unpleasant experience with one strain that is high in THC, but an enjoyable experience with another, simply because the ratio of the two compounds is different.


You’re familiar with terpenes even if you’ve never heard the word before. They are the lemon in your Lemon Haze, the berry in your Blueberry Kush, the fuel in your Sour Diesel. Terpenes give our strains the scents and tastes we love, but can they also play a role in the high? The topic is in need of further research, and it is a fascinating question, but some anecdotal evidence seems to suggest that it can, in fact, make a difference.


What are cannabis terpenes and what do they do?

For example, a potential effect of limonene is said to be stress relief, and linalool may provide relaxed mood enhancement. It makes a kind of intuitive sense—linalool, for example, is also what gives lavender its signature scent, and no one questions the relaxing effects of lavender oil.

In the future, research will undoubtedly emerge to confirm the beneficial effects of terpenes, and cannabis consumers will be able to say with confidence which terpenes they prefer most.


If you’ve ever asked your folks if they smoked when they were young, you might have heard that they enjoyed it back in the day but can’t tolerate it now. While you may have assumed they simply became uncool once they had kids, the truth is that age may have a surprising role to play in enjoying a cannabis high.


Cannabis Study: How THC Affects Learning and Memory at Different Ages

A 2007 study on rats found a link between age and the effects of cannabis. Adolescent rats were reported to tolerate the effects of weed much better than their adult counterparts, who showed more signs of stress, anxiety, and suppressed movement.

More research on age still needs to be done, but it may be wise to reevaluate how much and what kind of cannabis you’re consuming if the last time you smoked was in your teens.


No two people are exactly alike, and the same can be said for a person’s cannabis tolerance. The aforementioned age affects tolerance, as well as other factors, including frequency of consumption, body chemistry, and how long you’ve been smoking. It’s important to know your own personal tolerance, so you know how much or how little to consume, especially when consuming with others who may have different tolerances.


THC Tolerance: Here’s Why T-Breaks Work So Quickly

At the end of the day, only you can ascertain what your tolerance is, and by doing so, you will be empowered to have the type of cannabis high you want—whether that be relief, medical benefits, enjoyment, creativity, or whatever other effects you seek.

Rae Lland's Bio Image

Rae Lland

Rae Lland is a freelance writer, journalist, and former editor for Weedist and The Leaf Online. With a focus on culture, music, health, and wellness, in addition to her work for Leafly, she has also been featured in numerous online cannabis publications as well as print editions of Cannabis Now Magazine. Follow her on Instagram @rae.lland

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  • Highway 69

    Good info in this article.
    My opinion which is totally anecdotal is what you eat and drink also affects your high. I used to avoid eating any “munchies” because I believed they brought me down. My belief was that the foods turned to sugars which in turn counter-acted the effects of the THC. I also avoided drinking any alcoholic beverages so as not to “contaminate” my buzz.

    Of course decades later, my elitist (snobby?) behavior has almost disappeared. Although I still won’t drink, I don’t shun any foods!

  • Mcozy333

    another major component is your essential fatty acid dietary uptake… how much ( EFAs) omega three you consume determines your endocannabinoid tone and the ECS lipid expression of made on the spot bio-synthesized, metabolized, intracellular ligands known as endocannabinoids ( endogenous signalling lipids created from cellular phospholipids) that maintain the ECS tone. our Brains consist of up to 45% of these high functioning Lipids that are secondary metabolites really…. our diets determine so much… ingesting cannabis provides man a form of already created lipid signalling events ( phytocannabinoids)… the cellular expression of already formed exocannabinoids in man drives the tone of the ECS and makes up for a lack of dietary EFAs we do not consume ETC…..

    key words – HUFAS / PUFAS / Arachidonic acid / DHA / EPA / Eiocosanoids / prostaglandins / leukotrienes / lipophillic / terpenophillic / bio-regulatory biochemicals / phytochemicals / homeostasis

  • Hayley

    I’m new to Cannabis (42, female) I’ve tried several different medical strains. I’ve vaped (dry herb pax 3 and pax era cartridge) and made Cannabis butter but even at high doses I feel next to zero effects.

    I’ve been experimenting several times a week for the past month. I worried I was not inhaling correctly and made the Cannabis butter as a test. (Yes decarbed and precisely infused via Sous Vide) still nothing.

    Yes the strains have all have had THC (up to 25%)

    Any suggestions?? Maybe some just can’t get high?

    • Mcozy333

      pepercorns. eat a few peppercorns before your next dose… BCP- beta caryophyllene is a selective cb2 agonist… that means that the BCP selctivelly loads into your cb2 receptors… where does that leave the THC you arte wanting to feel ? this directs thc to your CB1 because BCP selectivelly loaded your cb2 receptors… peppercorns too can be used after the fact to reduce THC’ effects… the selective loading of cannabinoid type 2 recetprs ( cb2) is how it works for that…

      another thing you can try… eat a solid healthy meal with lots of fat. wait about 30 minutes then try your cannabis dose… this works mostly for edibles but can work for other delivery applications… first pass metabolism can be worked around up to about 45 minutes after you eat. the liver when you eat goes through first pass… you can get a metabolic response that works around first pass as the liver does not filter out for a while… this allows the plant cannabinods to make it further into digestion ( expression)….

      could possibly work out for you…

      another thing = cannabimimetics . you can titrate your cannabis dosage with other cannabimimetics… a great research article by Gertsh = Cannabimimetic phytochemicals in the diet–an evolutionary link to food selection andmetabolic stress adaptation?*

      I highly recommend you check that article, fascinating research

  • Ok now I know what to consume thanks much