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Try these limonene cannabis strains for anxiety, depression, and stress relief

Limonene is the second most common terpene in nature and a prominent terpene in cannabis. The fragrance of citrus fruit peels is comprised mostly of limonene, so you’d be correct to assume that this terpene takes its name from the lemon. Limonene’s pleasant odor has made it a common additive in perfumes and food.

Limonene can be safely consumed in high, naturally-occurring, amounts. However, adverse effects may be felt at doses around one gram per kilogram of body weight (around 68 grams of limonene for a 150-pound person). While this is significantly higher than what you’d find in cannabis flower or cannabis products, limonene extract can be purchased as a dietary supplement, so it’s advised that you consult a physician before adding substantial amounts of limonene to your diet.

Limonene is formed from geranyl pyrophosphate, the precursor to the cannabinoids. Once limonene is produced, it either stays in cannabis as limonene or gets converted to the other cannabis terpenes.

What are cannabis terpenes and what do they do?

As with many terpenes, plants produce limonene to help protect them against harmful microbes, and its antibacterial and antioxidant effects have been well-documented. But beyond its abilities to protect the plant, it also has an impact on brain function that scientists are working to better understand for the treatment of a variety of ailments—namely anxiety and other mental health disorders.

The potential benefits of limonene on anxiety, depression, and stress

Studies have found that both orally consumed limonene and inhaled limonene vapor reduces anxiety in lab mice. Similarly, limonene also reduced obsessive compulsive disorder-like behavior (OCD). However, limonene’s effectiveness seems to depend on mouse strain or type of anxiety test administered, perhaps indicating that its anxiety-reducing effects may work in some but not others.

Inhalation of limonene vapor increases serotonin and dopamine levels in key regions of the brain that are associated with anxiety, depression, and OCD.

Limonene may also have antidepressant qualities. Few human studies have been conducted on limonene’s antidepressant effects, but one small study of 12 hospitalized patients with depression revealed promising results. Limonene vapor inhalation reduced the need for antidepressant medication in 9 of the patients, normalized stress hormone levels, and improved immune function.

It remains unclear how limonene achieves these therapeutic effects. Inhalation of limonene vapor increases serotonin and dopamine levels in key regions of the brain that are associated with anxiety, depression, and OCD. At this point, it’s unclear how limonene boosts these brain chemical levels. Does limonene merely stimulate the brain’s olfactory system, or is it directly affecting brain cells, themselves? The actual mechanism is an area for future research, but it’s likely some combination of both stimulating the olfactory system and direct cellular action.

Limonene-dominant cannabis strains

As with most terpenes, precise levels of limonene often vary a lot between strains and across samples of a single strain. For example, the strain Cinex tends to have relatively high levels of limonene on average, but individual samples at your local cannabis shop may express less pronounced terpene profiles or limonene levels.

On average, these strains tend to be limonene-dominant in their terpene profiles:

Does limonene give strains a lemon aroma?

Short answer, not exactly.

The aroma that characterizes a strain is not due to one terpene, but rather a combination of all the terpenes that it contains.

The aroma that characterizes a strain is not due to one terpene, but rather a combination of all the terpenes that it contains. One terpene in isolation will have a very different aroma from many terpenes present in combination, even if that combination contains a lot of one terpene.

You can experience this first hand in certain dispensaries, many of which contain “terpene stations” that allow you to smell the aroma of individual terpenes. None of these smells all that much like cannabis flower, and the reason is that cannabis doesn’t contain just one terpene—it contains many.

So, even though limonene is found in lemons, that doesn’t mean that the presence of limonene can fully explain the aroma of a strain, even if it gives off a citrus aroma. For example, consider the terpene profiles of Lemon G and Lemon Meringue:

Lemon G

Lemon G cannabis terpenes

Lemon Meringue

Lemon Meringue cannabis terpenes

Both have “Lemon” in the name, but neither is limonene dominant. Limonene is the third most abundant terpene in Lemon G, after myrcene and caryophyllene. Lemon Meringue is terpinolene-dominant, and can contain multiple terpenes at higher levels than limonene.

Finding cannabis strains high in limonene

Knowing the name and even smelling the aroma of a strain may not be enough to tell you what it’s specific terpene profile is. The only way to know for sure what the terpene profile of a cannabis strain or product is is to have accurate lab testing results.

Unfortunately, most states do not require cannabis products to get tested for terpene levels, and most brands do not provide this information on product labels.

However, there are some cannabis brands that provide terpene profiles to consumers on product labels, and some retail locations are starting to carry these products more. If you’re interested in knowing the terpene profile of strain, ask your budtender if they carry any products with lab tested terpene profiles on the label.

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Josh Kaplan & Nick Jikomes's Bio Image
Josh Kaplan & Nick Jikomes

Josh Kaplan, PhD, is an Associate Professor of Behavioral Neuroscience at Western Washington University. He is a passionate science writer, educator, and runs a laboratory that researches cannabis' developmental and therapeutic effects.

Nick Jikomes is Leafly's principal research scientist. He completed his PhD in neuroscience at Harvard University in 2016.

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